Sperm donor's genetic mutation linked to cancer in 10 conceived children

Sperm from a single donor in Europe has reportedly been used to conceive at least pregnancies although the donor carried a rare cancer-causing mutation The donor s mutation has been linked to cancer diagnoses in of these children according to a overview by The Guardian The circumstance was brought to light after two families separately contacted their fertility clinics after their children's cancer diagnoses were linked to a rare genetic variant called TP PROSTATE CANCER DANGER INCREASES BY AMONG MEN WHO SHARE ONE TROUBLING BEHAVIORA mutation in the TP gene causes Li-Fraumeni syndrome which increases the liability of emerging cancer Cleveland Clinic states that this disorder comes with a chance of growing particular type of cancer by age and a chance by the age of The European Sperm Bank the sperm supplier verified that this variant was present in several of the donor s sperm The Guardian shared that the rare variant was not known to be linked to cancer at the time of donation in The genetic variant reportedly would not have been detectable through standard screening and the donor is commented to currently be in good fitness Dr Edwige Kasper a biologist at Rouen University Hospital in France presented this event at the European Society of Human Genetics annual conference in Milan last week commenting on the need for a European limit on the number of births or families for a single donor We can t do whole-genome sequencing for all sperm donors I m not arguing for that she described The Guardian But this is the abnormal dissemination of genetic condition Not every man has children across Europe TROUBLING CANCER TRENDS YOU MUST KNOW ABOUT IN Kasper analyzed the mutation in her lab concluding that it was the majority likely cancer-causing and that children born from this donor should receive genetic counseling The research-turned-investigation tracked down children from families in eight European countries The children were tested with the variant detected in of them The who had been diagnosed with cancer reportedly included cases of leukemia and non-Hodgkin lymphoma In a comment sent to Fox News Digital the European Sperm Bank stated that donor-assisted reproduction generally remains a significantly safer alternative than reproduction without genetic screening The bank added that sperm donors undergo a comprehensive fitness screening which includes an in-depth health examination a review of the donor s family health history and extensive testing for genetic and infectious diseases However it s not attainable to rule out all risks and in this particular event the identified mutation is one that could not have been detected by the screening methods we use in accordance with regulations and would require specialized genetic testing the group noted Julie Paulli Budtz VP of corporate communications at the European Sperm Bank expressed to Fox News Digital that they are deeply affected by this affair CLICK HERE TO SIGN UP FOR OUR VITALITY NEWSLETTER The donor has been thoroughly tested even beyond the required standards but preventative genetic screening is reaching its limits here she announced Every human being has about genes and it is scientifically merely not workable to detect disease-causing mutations in a person s gene pool if you don t know what you are looking for Budtz noted that the European Sperm Bank welcomes continued dialogue regarding setting an internationally binding family limit which they have advocated for on several occasions also at EU level This is also why in addition to complying with national pregnancy limits we have proactively implemented our own international limit of families per donor she added In the U S there is no official legal limit on how plenty of sperm donations one man can make However the American Society for Reproductive Medicine ASRM recommends that donors are limited to live births within each population area of people Institutions clinics and sperm banks should maintain sufficient records to allow a limit to be set for the number of pregnancies for which a given donor is responsible the ASRM states on its website California Cryobank which has claimed to have the largest selection of sperm and egg donations in the country states on its website that it closely monitors donors to limit the total number of family units to to worldwide Limiting donor vials is an essential part of the process the bank noted The U S Federal Drug Administration FDA requires that all sperm donors undergo a physical exam complete a questionnaire provide their curative history and undergo screenings for infectious diseases at an FDA-approved lab In addition the ASRM suggests that donors undergo psychological and genetic screening and also recommends infectious-disease testing of the recipient and the recipient's sexually intimate partners per its website For more Vitality articles visit www foxnews com robustness Legal consultation and laws may vary by state the organization notes At California Cryobank donors must be tested for infectious diseases undergo genetic screening get a psychological assessment and criminal background check and receive screening for the Zika virus according to the bank's website